类风湿关节炎患者静脉血栓栓塞发生率的Meta分析

Meta-analysis on incidence of venous thromboembolism in patients with rheumatoid arthritis

目的系统分析和评价类风湿关节炎患者发生静脉血栓栓塞的风险程度。方法电子检索已发表的国内外关于类风湿关节炎患者发生静脉血栓栓塞的相关文献,采用RevMan5.1软件进行数据分析,对于无法合并的数据采用描述性分析。结果共纳入10篇文献,对静脉血栓栓塞发生率、深静脉血栓发生率、肺动脉血栓栓塞发生率3个指标进行Meta分析,各指标RR值及95%CI分别为:2.00(1.71,2.33)、2.31(1.84,2.90)、2.25(2.23,2.28)。结论类风湿关节炎患者发生静脉血栓栓塞的风险程度高于非类风湿关节炎患者。

Objective To systematically analyze and assess the risk of venous thromboembolism in the patients with rheumatoid arthritis（RA）.Methods The related literatures on the venous thromboembolism occurrence in the patients with RA published at home and abroad were performed the electronic retrieval.The obtained data were analyzed by adopting the RevMan5.1software.The data unable to merge were analyzed by adopting the descriptive analysis method.Results A total of 10 related papers were included.The 3indicators of venous thromboembolism occurrence rate,deep vein thrombosis occurrence rate and pulmonary thromboembolism occurrence rate were performed the meta analysis.The RRand 95%CI of the occurrence rates of venous thromboembolism,deep vein thrombosis and pulmonary thromboembolism were 2.00（1.71,2.33）,2.31（1.84,2.90）,2.25（2.23,2.28）respectively.Conclusion The risk degree of venous thromboembolism occurrence in the RA patients is higher than that in the non-RA patients.