期刊文献+

细胞自噬与风湿免疫病 被引量:6

原文传递
导出
摘要 细胞白噬(autophagv)是细胞在自噬相关基因(autophagy related gene,atg)的调控下利用溶酶体降解自身受损的细胞器和大分子物质的过程,是以胞质内自噬体的出现为标志的细胞自我消化过程。广义上的自噬包括巨自噬(macmautophagy)、小自噬(mieroautophagy)和分子伴侣介导的自噬(chaperone-mediated autophagy,CMA)3种类型。在哺乳动物中研究最多的是巨自噬,即通常说的自噬。
作者 赵云 张奉春
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2016年第3期197-200,共4页 Chinese Journal of Rheumatology
  • 相关文献

参考文献27

  • 1Yang Z, Klionsky DJ. Eaten alive: a history of macroautophagy [J]. Nat Cell Biol, 2010, 12(9): 814-822. DOI: 10.1038/ncb 0910-814.
  • 2Choi AM, Ryter SW, Levine B. Autophagy in human health and disease[J]. N Engl J Med, 2013, 368(7): 651-662. DO1: 10. 1056/NEJMc1303158.
  • 3Rubinsztein DC, Codogno P, Levine B. Autophagy modulation as a potential therapeutic target for diverse diseases[J]. Nat Rev Drug Discov, 2012, 11(9): 709-730. DOI: lO.1038/nrd3802.
  • 4Fernandez D, Perl A. roTOR signaling: a central pathway to pathogenesis in systemic lupus erythematosus?[J]. Discov Med, 2010, 9(46): 173-178.
  • 5Gros F, Arnold J, Page N, et al. Macroautophagy is deregulated in murine and human lupus Tlymphocytes[J]. Autophagy, 2012, 8(7): 1113-1123. DOI: 10.4161/auto.20275.
  • 6Alessandri C, Barbati C, Vacirca D, et al. T lymphocytes from patients with systemic lupus erythematosus are resistant to in- duction of autophagy[J]. FASEB, 2012, 11(26): 4722-4732. DOI: 10.1096/fj. 12-206060.
  • 7Clarke A J, Ellinghaus U, Cortini A, et al. Autophagy is acti- vated in systemic lupus erythematosus and required for plas- mablast development[J]. Ann Rheum Dis, 2015, 74 (5) : 912- 920. DOI: 10.1136/annrheumdis-2013-204343.
  • 8Gateva V, Sandling JK, Horn G, et al. A large-scale replica- tion study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL-10 as risk loci for systemic lupus erythemat~sus[J]. Nat Geuet, 2009, 41( 11 ): 1228-1233. DOI: 10.I038/ng.468.
  • 9Zhou XJ, Lu XL, Lv JC, et al. Genetic association of PRDM1- ATG5 intergenic region and autophagy with systemic lupus ery- thematosus in a Chinese population[J]. Ann Rheum Dis, 2011, 70(7): 1330-1337. DOI: 10.1136/ard.2010.140111.
  • 10Zhou X J, Lv JC, Cheng WR, et al. Association of TLR9 gene polymorphisms with lupus nephritis in a Chinese Han population [J]. Clin Exp Rheumatol, 2010, 28(3 ) : 397-400.

同被引文献77

引证文献6

二级引证文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部