Presepsin对脓毒症诊断价值的Meta分析

Diagnostic Value of Presepsin for Sepsis: A Meta-analysis

目的系统评价Presepsin对脓毒症的诊断价值。方法计算机检索PubMed、EMbase、Web of Science、WanFang Data、VIP和CNKI数据库,搜集关于Presepsin诊断脓毒症的诊断性试验,检索时限均为从建库至2015年6月。由2位评价员独立筛选文献、提取资料,并采用QUADAS-2工具评价纳入研究的偏倚风险后,采用Stata13.0软件进行Meta分析。结果共纳入19个研究,4 140份标本。Meta分析结果显示:Presepsin诊断脓毒症的Sen_(合并)=0.85[95%CI(0.79,0.90)],Spe_(合并)=0.83[95%CI(0.76,0.87)],SROC曲线下面积为0.91[95%CI(0.88,0.93)]。结论 Presepsin作为一种新型诊断脓毒症标志物,展现出较好的诊断价值。但受纳入研究质量的限制,上述结论尚需开展更多高质量的研究予以验证。

Objective To systematically review the diagnostic value of Presepsin for sepsis. Methods We searched databases including PubMed, EMbase, Web of Science, WanFang, VIP and CNKI from inception to June 2015 to collect diagnostic tests related to Presepsin for spesis. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies by QUADAS-2 tool. Then, meta-analysis was performed by Stata 13.0 software. Results A total of 19 studies involving 4 140 samples were included. The results of meta-analysis showed that： the pooled sensitivity（Sen） and specificity（Spe） were 0.85（95%CI 0.79 to 0.90） and 0.83（95%CI 0.76 to 0.87）, respectively. The area under the summary receiver operating characteristic（SROC） curve was 0.91（95%CI 0.88 to 0.93）. Conclusion Presepsin shows high diagnostic value for sepsis as a novel biomarker. Due to the limited quality of the included studies, more high quality studies are needed to verify the above conclusion.