糖蛋白激素受体Lgr6的结构和功能

The structure and function of glycoprotein hormone receptor Lgr6

Lgr6是富含亮氨酸的G蛋白偶联受体，在人体组织中广泛分布，在胎盘、脑、心脏、肝、肺、小肠等均有表达。作为糖蛋白激素受体家族的新成员，目前尚未发现其生理性配体，故又称Lgr6为孤儿受体。研究发现，Lgr6标记的毛囊干细胞能分化成皮肤所有细胞系，参与皮肤更新及损伤修复，而且Lgr6在肿瘤组织中的表达也有重要的生物学意义。笔者对Lgr6的结构和功能进行综述。

Objective Leucine - rich repeat （LRR） - containing G protein - coupled receptor 6 （Lgr6） is glycoprotein hormone receptor and a part of G protein - coupled receptors （ GPCRs）. Lgr6 is composed of 977 amino acid residues of a polypeptide chain. Having 17 leucine - rich repeats and seven transmembrane domain. In the N - and C - termini are connected with cysteine - rich sequences. It is highest homologous to Lgr4 and LgrS, but less relationship with thyroid stimulating hormone receptor, progesterone receptor, and follicle - stimulating hormone recep- tor. Research found out that Lgr6 marks in the hair follicles of stem cells can differentiate into all cells in the skin and Lgr6 expression in tumor also has important biological significance.