COPD患者血清HIF-1α水平与心肾综合征的相关性研究

The correlation between serum hypoxia- inducible factor- 1α and cardiorenal syndrome in COPD patients

目的探讨慢性阻塞性肺疾病(COPD)患者血清缺氧诱导因子-1α(HIF-1α)水平与心肾综合征的相关性。方法纳入明确诊断为COPD的患者58例,以正常体检者30例为对照组。2组均采清晨空腹静脉血检测血清HIF-1α、胱抑素-C(Cys-C)、血清肌酐(Scr),并评估肾小球滤过率(e GFR),同时用心脏多普勒测定左室射血分数(EF)、左室舒张末期内径(LVEDD),分析比较2组患者上述指标的差异。结果与对照组比较,COPD组患者血清HIF-1α、Cys-C、LVEDD水平升高,EF降低,差异有统计学意义(P<0.05);2组间e GFR、Scr变化差异无统计学意义;COPD组各指标Perason相关分析,即血清HIF-1α和Cys C呈正相关性,与e GFR呈负相关性,与EF无相关性。结论 COPD患者慢性缺氧易并发心肾综合征,慢性缺氧患者血清HIF-1α可能是反映早期肾损伤、预测心脏损伤的生物标志物。

Objective To evaluate the relationship between serum hypoxia- inducible factor- 1α（ HIF- 1α） and cardiorenal syndrome in the patients with chronic obstructive pulmonary diseases（ COPD）. Methods There were 58 patients with COPD as experimental group and 30 normal people as control group. Routine renal function and laboratory markers of kidney injury were detected,which included serum creatinine（ Scr）,cystatin C（ Cys- C） and HIF- 1α. glomerular filtration rate（ e GFR） was calculated by CKD- EPI formula. A heart ultrasonic detection of left ventricular ejection fraction（ LVEF / EF） and ventricular end- diastolic diastolic（ LVEDD）were also collected and analyzed. Results Compared with control group,there was no significant difference in the levels of Scr and e GFR in COPD group. However,the levels of serum HIF- 1α,Cys- C and LVEDD were significantly increased in COPD group. Compared with the control group the LVEF / EF was significantly decreased in COPD group（ P〈0. 05）. Pearson analysis showed that serum HIF- 1αhad positive correlation with Cys- C. Meanwhile,serum HIF- 1α had positive correlation tendency with EF and negative correlation with e GFR. Conclusion Patients with COPD have a tendency to occur cardiorenal syndrome. Serum HIF- 1α may be a good predictive biomarkers for the early stage cardiorenal syndrome.