2型糖尿病肾病患者血清CA125水平分析

Analysis the influence on the level of the serum CA125 factor in type 2 diabetic nephropathy patients

目的探讨2型糖尿病肾病患者血清癌抗原125(CA125)水平与人血白蛋白的相关性。方法纳入34例确诊2型糖尿病肾病的患者,按照是否进入血液透析阶段分为2组,回顾性收集患者临床资料。血清CA125水平采用电化学发光免疫分析法测定,人血白蛋白水平用溴甲酚绿法测定,血清肌酐、尿素氮经自动生化仪检测,24 h尿蛋白定量由临床检验测定。结果 2组糖尿病肾病患者年龄、性别、糖尿病病程比较差异无统计学意义(P>0.05),2组间CA125、白蛋白、尿素氮及肌酐水平比较差异有统计学意义(P<0.05)。结论 2型糖尿病肾病患者的血清CA125水平与人血白蛋白密切相关,且人血白蛋白与是否进行血液透析密切相关。

Objective To investigate the correlation of the cancer antigen 125（ CA125） level in patients with type 2 diabetic nephropath and serum albumin. Methods According to whether enter the blood dialysis stage,34 patients who diagnosed type 2 diabetic nephropathy were divided into two groups. The serum levels of CA125 were detected by electrochemical luminescence immunity analysis,Serum albumin level was detected by bromocresol green. Serum creatinine and urea nitrogen were detected by automatic biochemical analyzer test. 24 hours urinary protein quantitative determination also was detected. Results There were no significant difference in patients＇ age,gender,diabetes duration（ P〈0. 05）. There were a significantly different in CA125,albumin,urea nitrogen and creatinine（ P〈0. 05）. Conclusion The serum CA125 in type 2 diabetic nephropathy patients are closely associated with serum albumin. The serum albumin is closely related to hemodialysis.