补体C3与IgA肾病的相关性研究

The correlation between complement C3 and IgA nephropathy

目的探讨补体C3与IgA肾病的关系,为IgA肾病的治疗及预后分析提供理论依据。方法回顾性分析肾活检确诊为原发性IgA肾病47例住院患者的临床及病理资料。根据补体水平将上述患者分为低补体组12例与正常补体组35例,分析2组间临床表现及病理特点。结果相比较于正常补体组患者,低补体组患者血清肌酐明显升高,而免疫球蛋白A及血清补体C3则明显降低,差异有统计学意义(P<0.05);2组患者肾脏病理中硬化小球、新月体数目上差异无统计学意义(P>0.05)。2组患者Hass分级相比较,低补体组患者肾脏病理与正常补体组肾脏病理分级差异无统计学意义(P>0.05)。结论 IgA肾病患者出现低补体血症可能提示患者肾功能恶化。

Objective To explore the relationship between the complement C3 and Ig A nephropathy. Methods 47 patients with Ig A nephropathy which diagnosed by renal biopsy were recruited into the study. All patients were classified into two groups according to the level of serum complement C3. Results Compared with the patients with normal serum C3 level,patients with decreased serum C3 level had higher serum creatinine level and lower serum Ig A level（ P〈0. 05）. Compared with the patients with normal serum C3 level,there was no significant difference in sclerotic glomeruli and crescent（ P〈0. 05）. There was no significant difference in kidney pathological grade of the two groups. Conclusion Decreased serum complement C3 level may indicate worse renal function in patients with Ig A.