左氧氟沙星治疗耐多药肺结核的疗效和不良反应探讨

To Explore the Efficacy and Adverse Reaction of Levofloxacin in Treatment of Multi Drug Resistant Pulmonary Tuberculosis

目的对耐多药肺结核患者接受左氧氟沙星治疗的临床效果进行探讨,分析该药物治疗的安全性。方法根据2012年10月~2014年2月我院的86例耐多药肺结核患者进行研究分析,将患者分组为对照组和观察组,均有43例,对照组使用常规的抗结核治疗方式,观察组除此之外增加左氧氟沙星治疗,两组患者进行18个月的治疗,对其治疗效果以及临床不良反应情况进行统计分析比较。结果患者的痰菌转阴率和病灶吸收情况为观察组较为优秀,差异具有统计学意义,P〈0.05。两组不良反应情况对比,差异不具有统计学意义,P〉0.05。结论耐多药肺结核患者可以选择左氧氟沙星治疗,其具有比较高的痰菌转阴率和病灶吸收率,患者的预后效果好。

Objective To investigate the clinical effect of levofloxacin in the treatment of multi drug resistant pulmonary tuberculosis patients, and to analyze the safety of the drug treatment. Methods Selected 86 patients with resistant pulmonary tuberculosis patients with multi drug from October 2012 to February 2014 in our hospital to research and analysis, which were divided into the observation group and the control group, each group had 43 cases, the control group using conventional anti tuberculosis treatment, the observation group in addition to the increase of levofloxacin, two groups of patients were 18 months of treatment, the treatment effect and adverse reactions were statistically analyzed and compared. Results Patients with sputum negative conversion rate, focus absorption into the observation group was more outstanding, and the result was statistically difference, P〈0.05. The adverse reactions of the two groups were not statistically different, P〉0.05. Conclusion Resistant multi drug tuberculosis patients can choose levofloxacin treatment, it has relatively high sputum negative conversion rate, focus absorption rate, the patient＇s prognosis can promote the use.