抗原非特异性T细胞对天然免疫炎性反应的调控

Regulation of innate inflammation by antigen non-specific T cells

天然免疫是抵御微生物入侵的第一道防线,其稳态的建立与维持须受到精确调控。近期研究进展表明,传统意义上抗原特异性免疫细胞——T细胞,能够以抗原非特异的方式在天然免疫阶段调节炎性反应,并决定了机体对微生物的免疫应答稳态。因此,深入了解T细胞以及不同T细胞亚型对天然免疫炎性反应的调控机制,有助于绘制天然免疫新的调控网络,阐述炎性疾病的发病机制,并提供新的治疗策略。

Innate immune response is the first line of defence against invaded pathogens, thus a precise regulation is required to establish and maintain such an innate homeostasis. Emerging evidence has shown that T cells, conventionally functioning in an antigen-specific manner, retains the capability of pathogenic antigen non-specific response, which fundamentally determines the outcome of innate inflammatory response to pathogen infections.Therefore, a better understanding of the mechanisms of how T cells respond and regulate innate inflammation helps to draw a novel regulatory network for innate-immunity, and provide a new dimension to understand the immune pathogenesis and immune intervention against infections.