胸腺肽联合雾化治疗小儿支气管哮喘疗效观察

Clinical observation on thymosin joint atomization in the treatment of infantile bronchial asthma

目的:观察胸腺肽联合雾化治疗对小儿支气管哮喘的治疗作用。方法:76例患儿均经临床确诊为支气管哮喘,并随机分为试验组及对照组,试验组在经验治疗的基础上予胸腺肽5 mg肌注,隔日一次,2周为1个疗程。同时给予布地奈德雾化1周。对照组给予常规吸氧,抗炎,平喘等哮喘控制治疗。结果:试验组显效25例,有效10例,无效1例,对照组显效11例,有效19例,无效10例。同时试验组较对照组患儿CD3,Ig G升高更明显,而CD4下降,两组比较,差异有统计学意义(P<0.05)。结论:胸腺肽通过免疫调节作用对哮喘有治疗作用,联合雾化效果更佳,值得临床推广。

Objective To observe thymosin joint aerosol therapy in the treatment of infantile bronchial asthma. Method 76 cases were clinically diagnosed as bronchial asthma,and randomly divided into experimental group and control group,experimental group on the basis of the experience of treatment for the 5 mg thymosin intramuscular injection,Every other day at a time,2weeks for a period of treatment. At the same time give budesonide atomization 1 week. The control group given conventional oxygen,anti- inflammatory,smooth wheezing such as the treatment of asthma control. Results Experimental group 25 cases had marked effect,10 cases were effective and ineffective in 1 case and control group in 11 cases were markedly effective,effective 19 cases,10 cases were invalid. At the same time,the experimental group than the control group with CD3,Ig G rise more obvious,and CD4 decline,differences between the two groups had statistical significance（ P〈0. 05）. Conclusion Thymosin through immune regulation has therapeutic effect on asthma,joint better atomization effect,worth clinical promotion.