放射性粒子组织间植入治疗直肠癌术后局部复发和盆腔转移病灶

Interstitial implantation of ^125I seeds for local and pelvic recurrence of rectal cancer

目的明确^125I放射性粒子肿瘤内永久植入治疗直肠癌术后局部复发和盆腔转移病灶的意义及粒子植入路径。方法回顾分析超声引导下^125I放射性粒子治疗的8例直肠癌术后局部复发和盆腔转移患者临床资料，观察治疗效果。结果5例间断血便和2例阴道不规则流血患者术后21-30d出血症状消失。术前疼痛的7例术后疼痛缓解，术后影像学检查治疗病灶均未见肿瘤进展。结论^125I放射性粒子治疗可有效提高直肠癌术后局部复发和盆腔转移患者的生活和生存质量。

objective To clarify the significance and puncture path of ^125I radioactive seeds implantation in treatment of postoperative local recurrence and pelvic metastasis in patients with rectal cancer. Methods Clinical data of 8 rectal cancer patients with postoperative local recurrence and pelvic metastasis treated by ultrasound guided ^125I radioactive seed implantation were retrospectively analyzed and the therapeutic effects were observed. Results After the treatment, the symptoms of 5 cases suffering from hematochezia and 2 cases with vaginal bleeding disappeared within 21 to 30 days. 7 patients with preoperative pain relieved after treatment. There was no tumor progression from postoperative imaging examination. Conclusion ^125I radioactive seed implantation can effectively improve the life quality of rectal cancer patients with postoperative local recurrence and pelvic metastasis.