摘要
miRNA是一类内源性的小分子非编码RNA，具有转录后基因调控功能，广泛参与细胞分化、增殖、发育及凋亡等生物过程，其表达失调可引起肿瘤。越来越多的证据表明，miRNA在甲状腺乳头状癌（PTC）中存在异常表达，其在PTC侵袭性作用机制、临床诊断价值、疗效评估、复发监测及预后判断等方面具有重要价值。
MiRNAs represent a class of short endogenous non-coding RNAs regulating gene expression at mRNA post-transcriptional level in many biological processes, including differentiation, proliferation, development and apoptosis. The deregulation of miRNA expression is believed to be an important regulator of tumor development. Increasing evidence has revealed the abnormal expression of miRNA in papillary thyroid carcinoma,indicating the important role in PTC invasion mechanism, clinical diagnostic value, efficacy evaluation, recurrence monitoring and prognosis judgement.
出处
《中华内分泌外科杂志》
CAS
2016年第1期71-73,77,共4页
Chinese Journal of Endocrine Surgery
基金
浙江省医药卫生科技计划项目（2014KYB203）
浙江省杭州市重大科技创新专项项目（20131813A08）
浙江省杭州市医药卫生科技计划项目（2012B004）
