益气健脾活血法治疗慢性复发型溃疡性结肠炎

Yiqijianpihuoxue medicine treatment of chronic recurrent relapsing ulcerative colitis

目的研究益气健脾活血组方治疗慢性复发型溃疡性结肠炎(UC)的临床疗效观察和对疾病复发率的影响。方法将慢性复发型UC随机分为2组各40例,治疗组给予自拟益气健脾活血组方药物,疗程12周,对照组给予美沙拉嗪胶囊4.0 g/d,疗程12周,进行临床症状及结肠镜表现的评定,随访24周的复发测定。结果自拟益气健脾活血药物治疗慢性复发型UC有效,治疗前症状积分为(8.3±0.98),治疗后(2.4±0.87),结肠镜表现积分治疗前为(9.14±1.01),治疗后为(3.17±0.71),与对照组比较无统计学意义(P>0.05),且复发率下降。结论益气健脾活血组方药物能有效治疗慢性复发型UC,并降低其复发率。

Objective To observe the effect of Yiqijianpihuoxue medicine in the treatment of the chronic recurrent relapsing ulcerative colitis patients and its effects on the recurrence rate. Methods The patients with relapsing ulcerative colitis were randomly divided into two groups,every group have 40 persons,the therapy group was treated with Yiqijianpihuoxue medicine,the control group was given mesalazine 4. 0g/every day,observe the clinical symptom score,score under colonoscopy at baseline and 12 weaks after treatment,and during 24 weaks the disease recurrence rate. Results The curative effect of Yiqijianpihuoxue medicine in treating relapsing ulcerative was remarkable,the symptom score before treatmentand（ 8. 3 ± 0. 98）,after treatment（ 2. 4 ± 0. 87）,the Colonoscopy integral before treatment（ 9. 14 ± 1. 01）,after treatment（ 3. 17 ± 0. 71）,compared with the control group not significant（ P 〉0. 05）,and reduce the recurrence rate. Conclusion Yiqijianpihuoxue medicine is effective in treatment of relapsing ulcerative colitis,and reduces the recurrence rate.