血浆D-二聚体与小儿大叶肺炎的相关性研究

Study on the correlation between plasma D-dimer and lobar pneumonia of Children

目的:研究探讨血浆D-二聚体对小儿大叶肺炎早期诊断、病情轻重和判断预后的价值。方法:选择120例肺炎患儿,其中普通肺炎60例,大叶性肺炎60例,另选取健康组60例。干预前后空腹抽血进行D-二聚体水平检测,比较不同组别患者D-二聚体水平差异,并通过临床、体征及支气管镜镜下表现进行其与病情严重度的相关分析。对所有患儿进行血浆D-聚体检测,并对大叶肺炎组行支气管镜检查。结果:普通肺炎组、大叶肺炎组、健康组检测的D-二聚体水平差异具有显著性,P<0.05;普通肺炎组和大叶肺炎组的D-二聚体水平明显高于健康组,差异具有显著性,P<0.05;重症肺炎组的D-二聚体水平明显高于普通肺炎组,差异有显著性,P<0.05。结论:血浆D-二聚体的质量浓度越高,患儿临床症状、体征越重,支气管镜镜下表现肺损伤重,肺部感染重,提示其对小儿大叶肺炎的早期诊断、病情轻重和判断预后有重要的临床意义。

Objective Study of plasma D-dimer two,to explore the early diagnosis of children with lobar pneumonia,severity and prognosis. Methods 2014 January to September 2015 in our hospital pediatric center hospital of 120 cases of pneumonia,including 60 cases of common pneumonia,60 cases of lobar pneumonia and other select 60 cases of healthy group,fasting blood before and after the intervention of D-dimer level detection,comparing different groups of patients with D-dimer level difference,and through clinical,signs and bronchoscopic performance and its correlation with the severity of. Of all the children of plasma D dimer detection,and lobar pneumonia group underwent bronchoscopy. Result Common pneumonia and lobar pneumonia group and healthy group detection of D-dimer level differences were significant,P〈0.05. Ordinary pneumonia group and lobar pneumonia group of D-dimer level was significantly higher than that of healthy group,and the difference is significant,P〈0.05. In severe pneumonia group of D-dimer level was significantly higher than that of ordinary pneumonia group,the difference was significant P〈0.05. Conclusion Plasma D-dimer body mass concentration is high,the clinical symptoms in children,symptoms heavier,the bronchoscope under lung injury heavy,serious pulmonary infection,suggesting that its early diagnosis of children with lobar pneumonia,severity and prognosis have important clinical significance.