摘要
Since significant ocular differences in both anatomical structure and optical properties exist between rodents and humans, clinical imaging devices for human use are not suitable for use on rodents. In this study, we develop a contact probe with a flexible surface that can closely fit the rodent cornea for fundus imaging with a confocal scanning laser ophthalmoscope. Both Zemax simulation and in vivo fundus imaging demonstrate that this con- tact probe can significantly improve both the imaging quality and the operational convenience.
Since significant ocular differences in both anatomical structure and optical properties exist between rodents and humans, clinical imaging devices for human use are not suitable for use on rodents. In this study, we develop a contact probe with a flexible surface that can closely fit the rodent cornea for fundus imaging with a confocal scanning laser ophthalmoscope. Both Zemax simulation and in vivo fundus imaging demonstrate that this con- tact probe can significantly improve both the imaging quality and the operational convenience.
基金
supported by the Doctoral Fund of the Ministry of Education of China (No. 20130001110035)
the National Key Instrumentation Development Project (Nos. 2011YQ030114 and 2013YQ030651)
the National Science Foundation of China (No. 30831160516)
the Guangdong Innovative Research Team Program (No. 2011S090)
the Beijing Municipal Science and Technology Commission (Pu M)
