熊果酸和齐墩果酸抗脑瘤作用的研究进展

Research progress on effects of ursolic acid and oleanolic acid against brain neoplasms

熊果酸和齐墩果酸广泛存在于蔬菜、水果和中草药里,并被广泛研究。二者不仅同属五环三萜酸类化合物,又是同分异构体,药理作用几乎相同,都具有抗炎、抗变态反应、抗微生物、降血糖、调血脂、减肥、抗动脉粥样硬化、抗骨质疏松、保肝和免疫调节以及抗焦虑、抗抑郁、改善学习记忆等作用。熊果酸和齐墩果酸还具有广谱抗肿瘤作用,包括呼吸系肿瘤、消化系肿瘤、性器官肿瘤、皮肤癌和白血病等。综述熊果酸和齐墩果酸抗脑瘤作用及其机制的研究进展,为新药研发提供依据。

Ursolic acid and oleanolic acid, both belonging to pentacyclic triterpene carboxylic acid, exit in many plants（vegetable, fruit, and herb）, are extensively researched, and are isomers yet. Their pharmacologic effects are fully alike. Ursolic acid and oleanolic acid have the pharmacologic effects of anti-inflammation, anti-allergy, anti-microbe, hypoglycemia, lipidemic regulation, antiobesity, antiatherosclerosis, anti-osteoporosis, hepatoprotection, immunomodulation, anti-anxiety, antidepression, and improvement of study and menory. Ursolic acid and oleanolic acid yet have broad antitumor effects, inclusive of leukemia, skin cancer, sexual organ carcinoma, digestive systemic tumor, and respiratory systemic tumor. In this paper, research advances in the effects and mechanisms of ursolic acid and oleanolic acid against brain neoplasms are reviewed.