基础胰岛素联合阿卡波糖对初诊老年糖尿病患者血糖水平及并发症的影响

Effect of basal insulin combined with acarbose on blood glucose level and complications in patients with newly diagnosed elderly diabetes

目的：分析基础胰岛素联合阿卡波糖对初诊老年糖尿病患者血糖水平及并发症情况的影响。方法：2012年7月~2015年1月间河北医科大学第一医院收治的初诊老年糖尿病患者135例作为研究对象,按照治疗方式不同分为观察组66例,对照组69例。对照组患者接受单纯阿卡波糖治疗,观察组患者接受基础胰岛素联合阿卡波糖治疗,对比两组患者的血糖水平、氧化应激指标、神经传导速度、血管损伤及炎症因子水平等差异。结果：治疗后观察组患者的FPG、2hPG、HbA1C水平低于对照组患者（P〈0.05）;AGE-P、MDA、NADPH水平低于对照组患者,SOD水平高于对照组患者（P〈0.05）;正中MNCV、尺MNCV、胫MNCV、正中SNCV、腓SNCV水平高于对照组患者（P〈0.05）;sVCAM-1、hsCRP、IL-6水平低于对照组患者（P〈0.05）。结论：初诊老年糖尿病患者接受基础胰岛素联合阿卡波糖治疗,可以有效优化血糖及并发症相关因子水平,具有积极的临床意义。

Objective：To analyze the effect of basal insulin combined with acarbose on blood glucose level and complications in patients with newly diagnosed elderly diabetes.Methods：A total of 135 cases with newly diagnosed elderly diabetes who were treated in our hospital from July 2012 to January 2015 were enrolled as research subjects and divided into observation group（66cases）and control group（69cases）according to different treatment methods.Control group received acarbose therapy alone,observation group received basal insulin combined with acarbose therapy,and then differences in blood glucose level,oxidative stress indicators,nerve conduction velocity,vascular injury and inflammatory factor levels of two groups were compared.Results：FPG,2hPG and HbA1 Clevels of observation group after treatment were lower than those of control group（P〈0.05）;AGE-P,MDA and NADPH levels were lower than those of control group,and SOD level was higher than that of control group（P〈0.05）;median MNCV,ulnar MNCV,tibial MNCV,median SNCV and sural SNCV levels were higher than those of control group（P〈0.05）;sVCAM-1,hs-CRP and IL-6levels were lower than those of control group（P〈0.05）.Conclusion：Basal insulin combined with acarbose therapy for patients with newly diagnosed elderly diabetes can effectively optimize the levels of blood glucose and complication-related factors,and it has active clinical significance.