老年湿疹患者Th1/Th2细胞因子的血清水平与湿疹的发展及其临床表现的相关性

Serum levels of Th1/Th2 cytokines in aged patients and their correlation with eczema development and clinical manifestation

目的:研究分析老年湿疹患者Th1/Th2细胞因子的水平变化与患者疾病发展及临床表现的关系。方法:选取本院皮肤性病门诊确诊的60岁以上的老年人92例(湿疹组)和60例健康老年人(健康组)作为研究对象,检测两组血清Th1/Th2细胞因子水平并进行比较,并根据患者临床表现进行分层分析。结果:湿疹组患者的IL-2、IL-4、IL-10、IL-12、TNF-ɑ、IFN-γ水平均显著的高于健康组人群且差异均具有统计学意义(P<0.05);湿疹组急性期患者的IL-2、IL-4、IL-10、IFN-γ水平均显著的高于健康组人群且差异均具有统计学意义(P<0.05);急性期与慢性期湿疹患者的IL-12、TNF-ɑ水平差异无统计学意义(P>0.05)。湿疹组患者泛发性和局限性的IL-2、IL-4、IL-10、IL-12、TNF-ɑ、IFN-γ水平均差异均不具有统计学意义(P>0.05)。结论:湿疹患者的Th1/Th2细胞因子的水平发生显著的改变较正常人群,尤其是急性期患者改变更为显著。

Objective：To investigate variations of Th1/Th2 cytokine levels,as well as their correlation with eczema development and clinical manifestation in aged patients.Methods：A total of 92patients（above 60 years old）with eczema diagnosed by the outpatient department of dermatology and venerology of our hospital were included as the eczema group,while 60 aged patients without eczema as the healthy group.Patients＇ serum levels of Th1/Th2 cytokines were examined for inter-group comparison and stratified analysis as per clinical manifestation.Results：Serum levels of interleukin（IL）-2,IL-4,IL-10,IL-12,tumor necrosis factor（TNF）-ɑand interferon（IFN）-γwere all significantly higher in patients of the eczema group than the healthy group（P〈0.05）.Acute stage levels of IL-2,IL-4,IL-10 and IFN-γwere significantly higher in patients of the eczema group than the healthy group（P〈0.05）.There was no significant difference in the levels of IL-12 and TNF-ɑbetween patients of the acute stage and those of the chronic stage（P〈0.05）.And no significant difference existed in the levels of IL-2,IL-4,IL-10,IL-12,TNF-ɑand IFN-γbetween generalized and localized eczema patients（P〈0.05）.Conclusion：Compared with the healthy population,Th1/Th2 cytokine levels are significantly different in eczema patients,especially those in the acute stage.