左主干解剖形态与左冠状动脉粥样硬化研究新进展

New Progress Between Left Main Coronary Anatomy and Left Coronary Atherosclerosis

左冠状动脉主干是指左冠状动脉发出后至分支前的节段,冠状动脉解剖形态是冠状动脉血流动力学与冠状动脉粥样硬化病变形成的一个关键性因素。以往的研究表明,因冠状动脉解剖形态造成的血流切应力变化在冠状动脉粥样硬化的发生和发展过程中起到重要作用,它的高低与血管壁厚度间存在负相关。在分叉处的外侧壁,血流切应力与粥样硬化斑块的形成密切相关。通过分析左冠状动脉主干的长度、分叉角度、直径等解剖因素,探讨左冠状动脉主干-长度、分叉角度、直径等潜在的血流动力学因素与左冠状动脉局部动脉粥样硬化斑块形成及左冠状动脉急性心肌梗死的相关性,了解左冠状动脉主干的长度、分叉角度、直径作为危险因素对左冠状动脉主干发生急性心肌梗死发生的价值,从而为冠心病患者预防急性心肌梗死的发生及相关高危人群的早期干预提供重要信息。

Left main coronary artery refers to the left coronary artery segments before branching. Coronary anatomy is a key factor in coronary hemodynamics and coronary atherosclerotic lesion formation. Previous studies showed that shear stress changes caused from coronary anatomy plays an important role in the occurrence and development of coronary artery atherosclerosis in blood vessels between its high and low wall thickness and the presence of a negative correlation. In the outer wall of the bifurcation,shear stress is closely related to the formation of atherosclerotic plaque. The length of the left main,bifurcation angle,diameter and other anatomical factors is analyzed and the left main length,bifurcation angle,diameter and other potential hemodynamic factors and the left coronary artery partial formation of atherosclerotic plaques and the left coronary artery relevance are explored. Additionally,it is important to know the length of the left main,bifurcation angle and diameter as a risk factor for the left main coronary artery in and when acute myocardial infarction value occurs,so as to prevent coronary heart disease in patients with acute myocardial infarction and to provide important information and early intervention to patients and population with related risk.