迷走神经刺激与心力衰竭

Vagus Nerve Stimulation and Heart Failure

随着心力衰竭发病机制研究的深入,发现迷走神经在心力衰竭的发生和进展中起着重要的作用。迷走神经活性降低是心力衰竭进展的重要因素,其可表现为静息心率增快,心率变异性和心率减速力下降等多个方面,而增强迷走神经活性可通过减慢静息心率,提高心率变异性,减少心肌炎症,提高一氧化氮合成扩张心脏血管,从而扭转或延缓心力衰竭的进程。目前临床应用越来越广泛,并取得了较好的治疗效果,未来会逐步成为治疗心力衰竭的常规方法之一。

With the study of the pathogenesis of heart failure,it is found that the vagus nerve plays an important role in the development of heart failure. Vagus nerve activity is an important factor in heart failure,which can be expressed as resting heart rate,heart rate variability and heart rate reduction. Additionally enhanced vagal activity can improve heart rate variability by slowing down resting heart rate,reduce the heart rate variability,improve the synthesis of nitric oxide,and then reverse or delay the process of heart failure. Presently,clinical application is widely increasing and has achieved good results. It will gradually become one of the methods for treating heart failure in the future.