晚钠电流与舒张性心力衰竭

Late Sodium Current and Diastolic Heart Failure

近年来,临床有越来越多心力衰竭患者伴左室射血分数正常,这使舒张性心力衰竭迅速演变成一个临床重要的独立病症,引起人们的广泛关注。晚钠电流的异常增强会引起心肌细胞内的钙离子超载,从而导致心脏的舒张功能出现障碍。现就舒张性心力衰竭和晚钠电流之间的关系做一综述。

In recent years,more and more patients with heart failure with normal left ventricular ejection fraction. This makes the diastolic heart failure quickly evolved into an important independent clinical symptoms and aroused people＇s wide attention. Late sodium current cause myocardial intracellular calcium overload,causing problems to the diastolic function of the heart. In the study,we review the relationship between the late sodium current and diastolic heart failure.