胃蛋白酶原相关影响因素分析

Influence Factors on Serum Pepsinogen

目的研究胃蛋白酶原(PG)与幽门螺杆菌(Hp)感染、性别、年龄、吸烟、饮酒等因素的关系。方法选取2014年1月至2014年12月在我院体检的上海市健康人群22270例作为研究对象,按Hp感染、性别、年龄、吸烟、饮酒情况分别比较PGⅠ、PGⅡ、PGR(PGⅠ/PGⅡ)的水平。结果 Hp阳性组:PGⅠ、PGⅡ显著高于Hp阴性组,PGR显著低于Hp阴性组,男性PGⅠ、PGR显著高于女性,PGⅡ显著低于女性。Hp阴性组:男性PGⅠ、PGⅡ、PGR显著高于女性。随着年龄增加,PGⅠ、PGⅡ逐渐升高,有统计学差异,PGR变化不大,仅≥70岁年龄组显著低于各年龄组。吸烟组PGⅠ、PGⅡ、PGR显著高于不吸烟组,PGⅠ、PGR显著高于曾吸烟组。曾吸烟组PGⅠ、PGⅡ显著高于不吸烟组,PGR无统计学意义。饮酒组PGⅠ、PGⅡ、PGR显著高于不饮酒组。结论胃蛋白酶原水平与幽门螺杆菌感染、性别、年龄、吸烟、饮酒均有关。

Objective To explore the relationship between serum pepsinogen（ PG） with helicobacter pylori（ Hp）infection,gender,age,smoking and drinking of people. Methods 22,270 cases of health examination people were involved in this study. The serum PG I,PG II and PGR（ PG I / PGII） were analyzed and compared by helicobacter pylori infection,gender,age,smoking and drinking of people. Results The serum levels of PG I and PG II in people with Hp positive were higher,while the level of PGR were lower than that of Hp negative.In people with Hp positive,the levels of PG I and PGR in male were higher,while PG II were lower than that of in female. In people with Hp negative,the levels of PG I,PG II and PGR in male were higher than that of in female. The levels of PG I and PG II were increased as the people＇s age increase. The levels of PGR in people over 70 years were lower than that of other people age group. The levels of PG I,PG II and PGR were higher in smoking people than that in non-smokers. The levels of PG I,PG II and PGR were higher in drinkers than that in non-drinkers. Conclusion The levels of PG might have some relations with Hp infection,gender,age,smoking and drinking of people.