肾间质纤维化中MicroRNA表达研究进展

Progress of MicroRNA Expression in Renal Interstitial Fibrosis

MicroRNA(miRNA)是一种高度保守、内源性的非编码小分子RNA,主要参与生物体中转录后水平基因表达的调控。miRNAs在各种肾脏疾病的发病机制中起重要作用。肾间质纤维化是各种慢性肾脏病进展至终末期,最终导致器官功能丢失的共同的病理过程和特征。转化生长因子β(TGF-β)在肾纤维化过程中是公认的一个重要的介质,它能刺激细胞外基质(ECM)的积聚并损害肾功能。近年研究发现,在肾脏组织中存在的一些miRNAs对肾脏纤维化的发生与发展有着重要的作用,深入地了解它们之间的关系可以为临床肾脏纤维化的治疗提供新的治疗靶点。

MicroRNA（ miRNA） is a highly conserved,endogenous non encoding small molecule RNA,which is mainly involved in the regulation of the expression of the gene in the organism. MiRNAs plays an important role in the pathogenesis of various renal diseases. Renal interstitial fibrosis is a common pathological process and characteristics of chronic kidney disease progression to the end,resulting in the loss of organ function.Transforming growth factor beta（ TGF-β） is an important medium in renal fibrosis,which can stimulate the accumulation of extracellular matrix（ ECM） and impair renal function. In recent years,some studies have found that some of the miRNAs in the kidney tissue has an important role in the occurrence and development of renal fibrosis. The understanding of relationship between them could provide a new therapeutic target for the treatment of renal fibrosis.