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肾损伤因子-1与慢性肾脏病 被引量:8

Kidney Injury Molecule-1in Chronic Kidney Disease
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摘要 慢性肾脏病是指各种原因引起的慢性肾脏结构和功能障碍(肾脏损伤病史〉3个月),包括肾小球滤过率(glomerular filtration rate,GFR)正常或不正常的病理损伤、血液或尿液成分异常及影像学检查异常,或不明原因的GFR下降[GFR〈60 mL/(min·1.73 m2)]超过3个月[1]。肾功能评估方法包括血尿素氮、肌酐及评估肾小球滤过率(estimated glomerular filtration rate,eGFR)的检测,但这些指标通常在肾损伤48~72 h后改变[2],敏感性、特异性欠佳。近年多项研究表明,
出处 《中国临床医学》 2016年第1期118-123,共6页 Chinese Journal of Clinical Medicine
基金 国家自然科学基金(编号:81270408 81570666) 中华医学会临床科研专项基金首届肾脏病青年研究基金(编号:13030300415) 江苏省"医学重点人才"项目(编号:RC201162) 江苏省"六大高峰人才"编号:2010(IB10)
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