碘佛醇对冠脉介入造影血清APN、hs-CRP、IMA及肾功能的影响

Effect of ioversol on serum APN,hs-CRP,IMA and renal function in patients with coronary angiography

目的探讨碘佛醇对冠脉介入造影患者血清脂联素(adiponectin,APN)、超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、缺血修饰清蛋白(ischemia modified albumin,IMA)及肾功能的影响。方法收集.浙江省三门县人民医院放射科收治的择期行冠状动脉介入造影的患者48例,根据碘佛醇使用剂量不同分为低剂量组(碘佛醇使用剂量<200 m L),高剂量组(碘佛醇使用剂量≥200 m L),每组各24例。术前及术后24 h,对所有患者的血清APN、hs-CRP、IMA及肾功能情况进行检测。结果术后24h,与对照组比较,高剂量组患者的血清APN水平显著降低,hs-CRP与IMA水平显著升高(P<0.05);高剂量组患者的血清Scr、BUN水平显著升高,尿β_2-MG水平显著升高(P<0.05)。结论碘佛醇能够降低冠脉介入造影患者血清APN水平,使血清hs-CRP、IMA水平升高,影响患者的肾功能,且使用剂量越大作用越强。

Objective To analyse the effect of ioversol on serum adiponectin（ APN）,high-sensitivity C-reactive protein（ hs-CRP）,ischemia modified albumin（ IMA） and renal function in patients with coronary angiography. Methods 48 patients who were undergoing elective coronary intervention in the hospital were collected. All patients were divided into low dose group（ 200 mL） and high dose group（ ≥200 mL） according to ioversol dose,24 cases in each group. Pre-surgery and 24 hours post-surgery,the serum levels of APN,hs-CRP,IMA and renal function were detected in all patients. Results After treatment,compared with low dose group,the serum APN level was significantly lower in high dose group（ P〈0. 05）; the serum hs-CRP level in high dose group was higher（ P〈0. 05）; the serum IMA level in high dose group was higher（ P〈0. 05）; the serum Scr and BUN levels and urinary β2-MG in high dose group were higher（ P〈0. 05）. Conclusion Ioversol could reduce the serum APN level in patients with coronary interventional angiography,elevated serum hs-CRP and IMA level,affected the patient＇s renal function,and the higher the dose,the more powerful.