逍遥丸对胃神经内分泌瘤患者血清嗜铬粒蛋白A、胃泌素及临床疗效的影响

Effect of Xiaoyao pill on serum CgA,gastrin and clinical efficacy in patients with gastric neuroendocrine tumor

目的探讨逍遥丸对胃神经内分泌瘤患者血清嗜铬粒蛋白A（chromogranin A,CgA）、胃及临床疗效的影响。方法收集四川绵阳市中心医院收治的急性脑梗死患者52例,随机分为对照组和实验组,每组各26例,对照组患者给予奥曲肽治疗,实验组在对照组治疗基础上给予逍遥丸治疗,治疗结束后,对所有患者的血清CgA、胃泌素水平及临床疗效进行检测。结果与对照组治疗后比较,实验组患者的血清CgA水平较低（P〈0.05）;实验组患者的血清胃泌素水平较低（P〈0.05）;实验组患者的总有效率较高（P〈0.05）。结论逍遥丸能够显著降低胃神经内分泌瘤患者血清CgA及胃泌素水平,提高治疗效果,对临床有指导意义。

Objective To analyse effect of Xiaoyao pill on serum Cg A,gastrin and clinical efficacy in patients with gastric neuroendocrine tumor.Methods 52 patients who were diagnosed with gastric neuroendocrine tumor in our hospital were collected. All patients were randomly divided into experimental group and control group,26 cases in each group. Patients in the control group received octreotide therapy,patients in the experimental group were treated with Xiaoyao pill on the basis of control group treatment,after the treatment,the serum levels of CgA,gastrin and clinical curative effect were detected in all patients. Results compared with control group post- treatment,the serum level of CgA was lower in the experimental group（ P〈0. 05）; the serum level of gastrin was lower in the experimental group（ P〈0. 05）; the total effective rate was higher in the experimental group（ P〈0. 05）. Conclusion Xiaoyao pill can significantly reduce the serum levels of Cg A and gastrin in patients with gastric neuroendocrine tumor,improve the treatment effect,and have a guiding significance for clinical.