用于减肥的新型药物Contrave

A drug used for weight loss: Contrave

Contrave是FDA新批准的用于肥胖患者减肥的口服缓释药物,是由2种药物成分纳曲酮和安非他酮组合而成,每片包含盐酸纳曲酮8 mg、盐酸安非他酮90 mg,2者合用对激动阿片促黑激素皮质素原(pro-opiomelanocortin,POMC)神经元具有互补和协同效应,能显著减轻肥胖患者体质量,并且无严重不良事件报道。本文对Contrave的临床前研究、临床试验、药代动力学以及不良反应等方面作一综述。

Contrave is approved by FDA as an oral extended-release drug used in obese patients＇ weight loss. Each tablet contains 8 mg of naltrexone hydrochloride and 90 mg of bupropion hydrochloride. And BUP ＋ NAL stimulated hypothalamic pro-opiomelanocortin（ POMC） neurons with a complementary and synergy effect. Contrave could reduce obese patients＇ body weight and has no serious adverse events. Contrave preclinical studies,clinical research,pharmacokinetics characteristics,adverse reactions are summaried in the article.