摘要
目的:介绍脉冲给药系统的释药机制及在其剂型药剂学中的应用进展。方法:查阅近年来的中外相关文献,对脉冲给药系统的释药机制及其剂型的发展情况进行综述。结果:脉冲给药系统的释药机制包括膨胀爆释、脉冲塞胶囊、生物化学和物理化学因素触发,其应用剂型主要有片剂、微丸、胶囊剂、膜剂、注射剂和栓剂。结论:随着医药水平的不断提高,满足时辰药理学的脉冲释制剂在未来的药剂学领域会有广泛的应用,具有良好的发展前景。
Objiective: To introduce progress in the release mechanisms and forms of pulse delivery system in the field of pharmacy. Methods: Release mechanisms of pulse drug delivery system and the development of forms were reviewed through searching the literature home and abroad in recent years. Results: The release mechanisms of pulse delivery system comprise the expansion burst release,pulse plug capsule,and trigger by biochemical,physical and chemical factors. It is mainly applied in tablets,pellets,capsules,films,injections,and suppositories. Conclusion: With increasing levels of medication,pulse release formulations meet chronopharmacological needs,and will be widely used in fields of pharmaceutics with good development prospects.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2016年第6期664-667,共4页
Chinese Journal of New Drugs
关键词
脉冲给药系统
释药机制
剂型
pulse delivery system
release mechanisms
formulations