摘要
目的探讨氟-代脱氧葡萄糖正电子发射型断层显像(18fluorodeoxyglucose positron emission tomography,^(18)F-FDG PET/CT)对直肠癌术后骶前复发的诊断价值。方法回顾性分析61例直肠癌Mile’s术后的患者,因发现骶前软组织病变行^(18)F-FDG PET/CT显像。图像分析采用视觉分析和通过半定量分析测量病变最大标准摄取值(SUVmax)。病例经手术病理学诊断或临床大于6个月以上的随访。计算^(18)F-FDG PET/CT显像诊断直肠癌术后骶前复发的敏感度和特异度。结果 61例直肠癌患者中,经病理学和随访最终诊断为骶前复发30例,骶前良性病变31例。骶前复发病变的SUVmax为9.44±3.78,良性病变SUVmax为2.24±2.15,两者差异具有统计学意义(t=9.10,P<0.01)。通过ROC曲线分析,以SUVmax为4.45是良恶性病变的界值,^(18)F-FDG PET/CT显像诊断直肠癌术后骶前复发的敏感度为96%,特异度为87%。曲线下面积为0.976。结论骶前复发性病变的^(18)F-FDG摄取值明显高于骶前良性病变,以SUV1max为4.45是良恶性病变的界值,8F-FDG PET/CT显像对直肠癌术后骶前复发具有很好的诊断价值。
Objective To assess the value of ^18F-FDG PET / CT in the diagnosis of presacral recurrence after Mile＇s operation for rectal cancer patients. Methods Sixty-one patients with presacral lesions after operation for rectal cancer underwent^18F-FDG PET / CT.The images were interpreted by visual and semi-quantitative analysis（ maximum standard uptake value,SUVmax）. All the cases were confirmed by pathology and clinical follow up（ 6 months）. The sensitivity,specificity of ^18F-FDG PET / CT for detecting presacral recurrence were calculated. Results Thirty cases were confirmed presacral recurrence of rectal cancer,and 31 cases were diagnosed as benign diseases. SUVmaxwas 9. 44 ± 3. 78 for recurrence lesions and 2. 24 ± 2. 15 for benign lesions. The uptake of ^18F-FDG was significantly higher in presacral recurrence lesions than in benign lesions（ t = 9. 10,P〈0. 01）. ROC curve analysis showed that a cutoff value of SUVmaxwas 4. 45 for benign and malignant lesions. The sensitivity of ^18F-FDG PET / CT was 96%,and the specificity was87%. The area under the ROC curve was 0. 976. Conclusion The uptake of ^18F-FDG in presacral recurrent lesions is higher than that in benign lesions. The cut-off value of SUVmaxis 4. 45 for malignant and benign lesions.^18F-FDG PET / CT in the diagnosis of presacral recurrence after operation for rectal cancer have a good diagnostic value.
出处
《山西医科大学学报》
CAS
2016年第3期289-293,共5页
Journal of Shanxi Medical University
基金
辽宁省科学技术计划基金资助项目(2010225032)
辽宁省科学技术计划基金资助项目(2012225013)
