阿片类药物预处理对依托咪酯注射所致肌阵挛影响的meta分析

Effect of Opiod Pretreatments on Etomidate Induced Myoclonus:A Meta-analysis

目的系统评价阿片类药物预处理对依托咪酯注射所致的肌阵挛的预防效果。方法由2名研究员独立检索PubMed,Cochrane Library,EMBASE,维普中文科技期刊数据库,万方医学数据库及CHKD期刊全文数据库相关文献,应用Review Maneger 5.2及STATA 12.0软件进行meta分析。结果共纳入24个研究(2 396例患者)进行meta分析。结果显示预注μ和κ阿片受体激动药与安慰剂相比均可以减少依托咪酯注射所致的肌阵挛,其相对危险度及其95%可信区间分别为RR=0.19[95%CI(0.14,0.27)]和RR=0.22[95%CI(0.12,0.40)]。结论预注阿片类药物可以减少依托咪酯注射所致肌阵挛的发生率。

Objective To assess the effect of opiod pretreatment on etomidate induced myoclonus. Methods The pertinent literatttres were searched by two independent investigators from the following electronic databases： PubMed, Cochrane Library, EMbase, VIP, WanFang Data, and CHKD. Then the meta-analysis was performed by using RevMan 5.2 and STATA 12.0 software. Results A total of 24 RCTs involving 2 396 pa- tients were included for the study. Pretreatment of μ or K-receptor agonists reduced myoclonus with RR =0.19 （95%CI 0.14 to 0.27） and RR =0.22 （95%CI 0.12 to 0.40）, respectively. Conclusion Pretreatment of opiods can reduce the incidence of etomidate induced myoclonus.