非小细胞肺癌hMOF蛋白表达与放疗预后的关系

Correlation Study between hMOF Expression and Prognosis in Patients with Non-small Cell Lung Cancer after Radiotherapy

目的研究hMOF蛋白在非小细胞肺癌(NSCLC)中表达情况及其与NSCLC放疗预后的相关关系。方法采用SP免疫组化方法分别检测59例接受放疗的NSCLC患者中hMOF蛋白表达情况,分析其与临床病理特征及NSCLC放疗预后的相关关系。结果 59例NSCLC患者中hMOF蛋白高表达30例,高表达率50.85%。临床分期、hMOF蛋白表达水平是NSCLC放疗的独立预后因素。结论 hMOF蛋白表达水平与NSCLC放疗预后相关,是影响NSCLC放疗预后的指标。

Objective To investigate the hMOF protein expression in non-small cell lung cancer and explore the relationship between its expres- sion and radiotherapy prognosis. Methods Immunohistochemical staining was used to detect the hMOF expression in 59 cases of non- small cell lung cancer after radiotherapy. The relationship between hMOF expression with clinicopathological and radiation prognosis was analyzed. Results Among the 59 cases of non-small cell lung cancer tissues, there were 30 cases found to be high expression with hMOF. The rate of positive expression of hMOF in non-small cell lung cancer were 50.85%. Clinical stage and hMOF expression were independent predictors for non-small cell lung can- cer. Conclusion The expression of hMOF had a positive correlation with the radiation prognosis in non- small cell lung cancer, which could be used as a protmostic indicator of radiotherapy.