OSAHS与心血管疾病的研究进展

The research progress of OSAHS and cardiovascular disease

阻塞性睡眠呼吸暂停低通气综合征（obstructive sleep apnea hypopnea syndrome,OSAHS）是以夜间睡眠时上气道的反复狭窄或闭塞为主要特征进而引起间歇性缺氧（intermittent hypoxia,IH）的一类疾病,临床表现为白天嗜睡以及夜间打鼾伴呼吸暂停。据最新统计^（〔1〕）,中重度OSAHS在女性发病率高达15%~25%,男性则高达30%~50%。而同时,

Obstructive sleep apnea hypopnea syndrome（OSAHS）is characterized by recurrent stenosis or occlusion of upper airway during sleep.Although the controversy is far from over,this syndrome could often lead to different cardiovascular diseases（CVD）with those complicated pathophysiologic mechanisms,including hypertension,coronary heart disease,heart failure and cardiac arrhythmia.The objective of this article is to elaborate these related pathogenesis,and further to investigate the relationship between OSAHS and CVD.Besides,as one kind of effective and economical treatment,continuous positive airway pressure（CPAP）should be attached enough importance in the therapy of CVD with OSAHS.