阻塞性睡眠呼吸暂停低通气综合征中血清髓过氧化物酶检测的意义

The meaning of serum myeloperoxidase in obstructive sleep apnea hypopnea syndrome

目的:探讨外周血髓过氧化物酶(MPO)的检测对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者的临床意义。方法:选择我院60例OSAHS患者作为OSAHS组,根据PSG将其分为轻、中、重3组,各20例,20例健康体检者作为对照组;ELISA法检测外周血MPO水平,20例重度OSAHS患者治疗3个月后再次检测MPO水平,分析血清MPO水平与睡眠呼吸相关事件的各指标相关性。结果:1外周血清MPO浓度随OSAHS患者病情严重程度呈现递增趋势,对照组与轻、中、重4组研究对象血清MPO水平分别为(7.93±2.44)、(10.58±3.31)、(18.91±8.37)、(29.03±10.06)ng/mg(F=19.102,P<0.05);2OSAHS患者外周血MPO浓度与性别、年龄、BMI无关(P>0.05),与AHI呈正相关,与LSaO_2呈负相关(P<0.05);3通过综合治疗后,20例重度OSAHS患者血清MPO浓度及AHI较前下降,LSaO_2上升,差异有统计学意义(P<0.05)。结论:OSAHS患者血清MPO的检测对判断病情严重程度、评估治疗效果及对重度OSAHS患者患心血管疾病风险性的预测具有重要意义。

Objective：To investigate the clinical significance of detecting peripheral blood myeloperoxidase in OSAHS patients.Methd：Sixty cases of OSAHS patients in our hospital was selected as OSAHS group,which was subdivided into light,medium and heavy groups according to the PSG,each with 20 cases,and 20 cases of healthy persons were selected as control group;ELISA method was used to detect the MPO level of peripheral blood.20 cases of severe OSAHS patients detect MPO level again three months after the fist detection,and analyze the correlation between serum MPO level and indicators of sleep respiratory related events.Result：1The level of peripheral serum MPO level positively correlated with the severity of the patients＇ condition.The control group,light,medium and heavy groups＇ serum MPO levels were（7.93±2.44）,（10.58±3.31）,（18.91±8.37）,（29.03±10.06）ng/mg,respectively（F=19.102,P〈0.05）.2OSAHS patients＇ peripheral blood MPO concentration had no correlation with gender,age and BMI,but was positively correlated with AHI and negatively correlated with LSaO_2（P〈0.05）.3Twenty cases of severe MPO and AHI patients with OSAHS were decreased and LSaO_2 increased,the difference was statistically significant（P〈0.05）.Conclusion：The detection of serum MPO in patients with OSAHS has important significance in judging the severity of the disease,evaluating the treatment effect and predicting the risk of cardiovascular disease in patients with severe OSAHS.