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Wip1和p53在喉鳞状细胞癌组织中的表达及临床意义 被引量：3

Expression and clinical significance of Wip1 and p53 in laryngeal squamous cell carcinoma
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摘要 野生型p53诱导的磷酸酶1（wild-type p53-induced phosphatase 1,Wip1）是近年来新发现的一种原癌基因。研究发现,Wip1基因在多种人类肿瘤组织中高表达,且被认为与肿瘤的发生、发展有关。p53是一种重要的抑癌基因,约50%的人类肿瘤的发生与p53基因的突变及失活相关。
作者 陈应超 王玮 李兆龙 周洁 肖兰 刘汉忠
机构地区 孝感市中心医院耳鼻咽喉头颈外科 孝感市中心医院病理科
出处 《临床耳鼻咽喉头颈外科杂志》 CAS 北大核心 2016年第6期495-497,共3页 Journal of Clinical Otorhinolaryngology Head And Neck Surgery
关键词 喉鳞状细胞癌 WIP1 P53 免疫组织化学 laryngeal squamous cell carcinoma Wipl p53 immunohistochemistry
分类号 R739.65 [医药卫生—肿瘤]
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参考文献14

  • 1ZHU Y H,BULAVIN D V.Wip1-dependent signaling pathways in health and diseases[J].Prog Mol Biol Transl Sci,2012,106:307-325.
  • 2MEEK D W.Regulation of the p53response and its relationship to cancer[J].Biochem J,2015,469:325-346.
  • 3杨德华,张浩,胡新华,辛世杰,段志泉.甲状腺乳头状癌中p16/p53/p38MAPK/Wip1通路的改变及意义[J].中国普通外科杂志,2011,20(11):1199-1202. 被引量：9
  • 4BULAVIN D V,DEMIDOV ON,SAITO S,et al.Amplification of PPM1Din human tumors abrogates p53tumor-suppressor activity[J].Nat Genet,2002,31:210-215.
  • 5LOWE J,CHA H,LEE M O,et al.Regulation of the Wip1phosphatase and its effects on the stress response[J].Front Biosci,2012,17:1480-1498.
  • 6YANG D H,HE J A,LI J,et al.Expression of protooncogene Wip1in breast cancer and its clinical significance[J].Zhong Hua Yi Xue Za Zhi,2010,90:519-522.
  • 7LIU S,QI L,HAN W,et al.Overexpression of wip1is associated with biologic behavior in human clear cell renal cell carcinoma[J].PLoS One,2014,9:e110218-e110218.
  • 8FU Z,SUN G,GU T.Proto-oncogene Wip1,a member of a new family of proliferative genes in NSCLC and its clinical significance[J].Tumour Biol,2014,35:2975-2981.
  • 9SUN G G,ZHANG J,MA X B.Overexpression of Wild-Type p53-Induced Phosphatase 1 Confers Poor Prognosis of Patients with Nasopharyngeal Carcinoma[J].Pathol Oncol Res,2015,21:283-291.
  • 10ZHANG Y,SUN H,HE G,et al.WIP1regulates the proliferation and invasion of nasopharyngeal carcinoma in vitro[J].Tumour Biol,2014,35:7651-7657.

二级参考文献35

  • 1刘鹏,刘艳,孙慧.小鼠乳腺癌中p53与bcl-2／bax基因表达的相关性研究[J].中华实验外科杂志,2007,24(2):176-178. 被引量：11
  • 2Bulavia DV , Demidov ON , Salto S, et al. Amp|ificatiou of PPM1 D in human tumors abrogates p53 tumor-suppressor activity[J]. Nat Genet, 2002, 31 (2) :210 -215.
  • 3Li J, Yang Y, Peng Y, et PPM! D located within a breast at 17q23 [ J ]. Nat Goner, 134. al. Oncogenic properties of cancer amplification epicenter 2002, 31 (2) : 133 -134.
  • 4Le Guezennec X, Bulavin DV. WIP 1 phosphatase at the cross- roads of cancer and aging [ J ] . Trends Biochem Sci , 2010 , 35(2) :109-114.
  • 5Yu E, Ahn YS, Jang S J, et al. Overexpression of the wipl gene abrogates the p38 MAPK/p53 / Wip 1 pathway and silences p 16 expression in human breast cancers [ J ]. Breast Cancer Res Treat, 2007, 101 (3) :269 -278.
  • 6Bulavin DV, Higashimoto Y, Popoff IJ, et al. Initiation of a G 2 / M checkpoint after ultraviolet radiation requires p 38 kinase[J]. Nature, 2001, 411 (6833) :102 - 107.
  • 7Lee JS, Lee MO, Moon BH, et al. Senescent growth arrest in mesenchymal stem cells is bypassed by Wip 1-mediated downregulation of intrinsic stress signaling pathways [ J ] . Stem Cells, 2009, 27(8) :1963 -1975.
  • 8Fuku T, Semba S, Yutori H, et al. Increased wild-type p5 3 -induced phosphatase 1 ( Wip 1 or PPM 1 D ) expression correlated with downregula~ion of checkpoint kinase 2 in human gastric carcinoma[ J ]. Pathol Int, 2007, 57 (9) : 566 -571.
  • 9Liu G, Chen X. Regulation of the p53 transcriptional activity[J]. J Cell Biochem, 2006, 97(3) :448 -458.
  • 10Yoda A, Toyoshima K, Watanabe Y, et al. Arsenic trioxide augments Chk2/p53-mediated apoptosis by inhibiting oncogenic Wipl phosphatase [ J I - J Biol Chem, 2008 , 283(27) :18969 - 18979.

共引文献14

同被引文献33

引证文献3

二级引证文献11

临床耳鼻咽喉头颈外科杂志
2016年 第6期

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