快速尿液单羟酚代谢物检测在恶性肿瘤中的诊断价值

Value of quick detection for urine monohydroxyphenyl metabolite in diagnosing malignant tumor

目的探讨尿液单羟酚代谢物检测在恶性肿瘤中的诊断价值。方法采用尿液单羟酚试剂盒对本院采集的1 100份尿液样本进行对羟基苯丙氨酸进行检测分析,其中健康者100例(对照组),非肿瘤患者121例(非肿瘤疾病组),病理确诊的恶性肿瘤患者879例(恶性肿瘤组),比较3组研究对象的尿液单羟酚代谢物的水平。结果尿液单羟酚代谢物检测试剂在检测恶性肿瘤、非肿瘤疾病、对照组中的阳性检出率分别为71.2%、20.7%和3%。在恶性肿瘤组中的阳性率明显高于其他组,恶性肿瘤组中消化道肿瘤组的阳性率(87.0%)高于非消化道肿瘤组(56.1%),差异均有统计学意义(P<0.05)。150例经影像及病理诊断的恶性肿瘤及非肿瘤疾病患者进行尿单羟酚检测,一致性检验显示,尿单羟酚试验结果与病理检测结果有中等程度的一致性(Kappa=0.476)。结论尿液单羟酚代谢物检测适用于恶性肿瘤的广谱筛查,特别对消化道肿瘤具有高敏感性及广谱性的优点。

Objective To investigate the diagnostic value of urine monohydroxyphenyl metabolite detection in malignant tumor.Methods The urine monohydroxyphenyl reagent kit was adopted to detect and analyze monohydroxyphenyl in 1 100 urine samples collected in our hospital,including 100 healthy persons（control group）,121 cases of non-tumor（non-tumor disease group）and 879 cases of pathologically diagnosed malignant tumor（malignant tumor group）.The monohydroxyphenyl metabolite levels were compared among 3groups.Results The positive rates of urine monohydroxyphenyl by using the monohydroxyphenyl reagent were 71.2%in the malignant tumor group,20.7%in the non-tumor disease group and 3%in the control group,respectively.The positive rate in the malignant tumor group was significantly higher that in the other groups,the positive rate in the digestive tract tumor group of the malignant tumor group was higher than that in the non-digestive tract tumor group（87.0% vs.56.1%,P〈0.05）.The consistence test of urine monohydroxyphenyl detection in 150 cases of imagiologically and pathologically diagnosed malignant tumor and non-tumor disease tumor showed that the urine monohydroxyphenyl detection results had the moderate degree of consistency with the pathological examination results（Kappa=0.476）.Conclusion The urine monohydroxyphenyl detection is suitable for screening malignant tumor,which has the advantages of high sensitivity and wide spectrum,especially for the digestive tract tumor.