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枳朮宽中胶囊治疗伴有焦虑抑郁状态的功能性消化不良临床研究 被引量:19

Clinical study of Zhizhu Kuanzhong capsule in treatment of patients with functional dyspepsia complicated with anxiety and depression
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摘要 目的观察枳朮宽中胶囊治疗伴有焦虑抑郁状态的功能性消化不良(Functional dyspepsia,FD)患者的临床疗效。方法将伴有焦虑抑郁状态的FD患者随机分为观察组(枳朮宽中胶囊组)及对照组(多潘立酮联合路优泰组),分别口服用药,疗程4周。用药前后分别进行FD临床症状评分、Hamilton焦虑量表评分(HAMA评分)及Hamilton抑郁量表评分(HAMD评分),用药期间记录两组患者出现的不良反应。结果两组患者治疗前FD临床症状评分、HAMA评分及HAMD评分差异无统计学意义(P>0.05)。观察组及对照组用药后FD临床症状评分、HAMA评分及HAMD评分较本组用药前均明显下降,差异有统计学意义(P<0.05)。两组间用药前后FD临床症状评分改善率、总有效率、HAMA及HAMD减分率比较差异均无统计学意义(P>0.05)。两组患者用药期间均未出现不良反应。结论枳朮宽中胶囊治疗伴有焦虑抑郁状态FD患者的疗效与多潘立酮联合路优泰相近,值得临床推广。 Objective To observe the clinical effect of Zhizhu Kuanzhong capsule in treating patients with functional dyspepsia( FD) complicated with anxiety and depression. Methods The patients were divided into observation group( Zhizhu Kuanzhong capsule group) and control group( domperidone and St John's wort extractive group)randomly,and they were respectively administered medication for 4 weeks. FD clinical symptom score,HAM A and HAM D were scored before and after treatment,and the side effects of each group were recorded. Results FD clinical symptom score,HAM A and HAM D score of each group had no significant difference before treatment( P〉0. 05). FD clinical symptom score,HAM A and HAM D score of each group had been obviously improved after treatment,the difference was statistically significant( P〈0. 05). The improvement rate of FD symptom,total effective rate,HAM A and HAM D reducing rate had no significant difference between the two groups after treatment( P〉0. 05). No adverse effect was observed in both groups during treatment. Conclusion Zhizhu Kuanzhong capsule has the same effect as domperidone and St John's wort extractive in treating FD with anxiety and depression and is worthy of clinical promotion.
作者 关霜霜 李岩
出处 《实用药物与临床》 CAS 2016年第3期296-299,共4页 Practical Pharmacy and Clinical Remedies
关键词 功能性消化不良 焦虑 抑郁 Functional dyspepsia Anxiety Depression
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