英夫利昔单抗治疗类风湿关节炎的临床研究

Clinical effect of infliximab in treatment of rheumatoid arthritis

目的探讨英夫利昔单抗治疗类风湿关节炎的临床疗效,为临床合理用药提供参考。方法回顾性分析我院风湿免疫科2013年10月至2015年6月收治的30例患者应用英夫利昔单抗治疗类风湿关节炎的情况,观察患者治疗前后症状、体征及实验室检查等情况。结果治疗后患者的血沉和CRP明显降低,病情活动情况明显减轻。30例患者中,1例出现局部注射反应,2 d内可自动消失。其余患者未发现明显不良反应。结论英夫利昔单抗能明显改善RA等风湿免疫疾病的炎症反应,抑制关节破坏进展,改善患者的临床表现及预后。

Objective To investigate the clinical effects of infliximab in the treatment of rheumatoid arthritis（ RA） and provide references for rational clinical drug use. Methods 30 patients at the Rheumatism and Immunology Department in our hospital were administered and were given infliximab to treat RA from Octorber 2013 to June 2015.The patients＇ pre-and post-treatment symptoms,signs,and progression were reviewed. Results After infliximab treatment,ESR and CRP of the 30 patients reduced,and their conditions were significantly improved. One of the 30 patients displayed local reactions at the injection site,which disappeared spontaneously within 2 days. There were no adverse events among the remaining patients. Conclusion Infliximab can suppress the inflammatory reaction of RA and rheumatic immunological diseases,inhibit the progression of joint damage,and improve the clinical manifestations and prognosis of patients.