黄芩苷对佐剂性关节炎血清中IL-1、IL-17、TGF-β表达的影响被引量：9

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摘要目的:通过检测黄芩苷对佐剂性关节炎大鼠治疗前后IL-1,IL-17与TGF-β在血清中的水平变化,并观察疗效,旨在从分子水平分析其对于佐剂性关节炎的治疗作用,以此为临床用药提供理论依据。方法:将Wistar大鼠随机分为四组,A组:正常组;B组:模型组;C组:药物对照组;D组:药物治疗组。A组给予0.9%的氯化钠0.1m L于大鼠足趾部;B、C、D三组各给予0.1%完全弗氏佐剂0.1m L于大鼠足趾部注射,在第6天给予加强注射免疫一次,造模后2周,A、B组给予0.9%的氯化钠灌胃,C组(药物对照组)给予柳氮磺吡啶40mg/kg灌胃处理,D组给予黄芩苷灌胃给药40mg/kg,每日一次,连续20d,之后用酶联免疫吸附实验对大鼠血清中IL-1、IL-17、TGF-β的水平进行检测。结果:C、D组中IL-1、IL-17水平明显低于B组,TGF-β的水平明显高于A、B组。结论:黄芩苷可明显降低血清中IL-1、IL-17的水平,提高TGF-β的表达水平。

作者高金灵李振英刘玮孙晓鹏

机构地区佳木斯大学临床医学院临床医学教研室

出处《黑龙江医药科学》 2016年第2期63-64,共2页 Heilongjiang Medicine and Pharmacy

关键词黄芩苷佐剂性关节炎 IL-1 IL-17 TGF-Β

分类号 R593.22 [医药卫生—内科学]

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参考文献6

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