维生素A与阿尔茨海默病关系的Meta分析

Association between Vitamin A and Alzheimer disease： a meta--analysis

目的系统评价维生素A与阿尔茨海默病（AD）之间的关系。方法检索PubMed、EM—Base、中国期刊全文数据库（CNKI）、万方数据库和维普数据库中有关维生素A与AD关系的病例对照研究文献，检索时间截至2015年3月。由2名研究者按照严格的纳入和排除标准筛选文献、提取资料，并进行方法学质量评价。运用Stata11．0软件进行Meta分析。结果共纳入8篇文献，研究对象共947例，其中AD患者290例，对照657名。经Meta分析显示，AD患者维生素A水平显著低于健康对照组，WMD=-0．333（95％CI=-0．544～-0．122，P〈0．05）。Egger’s检验显示无发表偏倚，剪补法显示结果较稳健。结论维生素A缺乏可能是AD的危险因素。

Objective To systematically review the association between Vitamin A and Alzheimer disease （AD）. Methods Case--control studies on the association between Vitamin A and AD were searched through PubMed, EMBase, Chinese National Knowledge Infrastructure database （CNKI）, Wanfang and VIP databases. All the articles were published until March 2015. Two reviewers independ- ently screened potentially relevant articles according to the inclusion and exclusion criteria. Stata 11.0 software was performed in this meta--analysis. Results In total, 8 studies with 947 participants met the eligibility criteria, which included 290 AD patients and 657 controls. The result of meta--analysis showed that the level of Vitamin A in subjects with AD was lower than controls （WMD =-0. 333,95%CI =-0. 544---0. 122, P 〈0.05）. Egger＇s test showed there was no published bias. Trim and filling method revealed that the result was robust. Conclusions Lack of Vitamin A may be a risk factor for AD.