慢性心力衰竭患者血浆生长分化因子15的诊断意义

The Plasma Growth Differentiation Factor 15 of Patients with Chronic Heart Failure and its Diagnosis Significance

该文研究血浆生长分化因子15(GDF-15)对心力衰竭(HF)的意义及与其严重程度之间的关系?方法:选取HF患者及NYHAⅠ级患者为研究对象,测定血浆GDF-15水平及左室射血分数?结果:HF组患者血浆GDF-15水平明显高于对照组,并随NYHA心功能分级的增加而升高?结论:HF患者血浆GDF-15水平明显升高,与心衰程度密切相关,血浆GDF-15水平是判断心衰严重程度有价值的指标?

Objective： The objective of the research is to investigate the significance of the plasma-growth differentiation factor 15（GDF-15） for the heart failure（HF） and the relation of GDF-15 to the severity of the heart failure. Its methods are that HF patients and NYHA patients were selected as the research objects, and their plasma GDF-15 levels and their left ventricular ejection fractions were measured. Its results show that HF patients＇ plasma GDF15 levels are significantly higher than the control group, and increase with the upgrade of NYHA functional classes. So the conclusion can be drawn that HF patients＇ plasma GDF-15 levels were significantly increased, which is closely related to the degree of heart failure, and that the plasma levels of GDF15 are an index to judge the severity of heart failure.