探讨2型糖尿病并发脑卒中血清学指标的检测及临床意义

Type Ⅱ diabetes mellitus serum markers of stroke and its clinical significance

目的探讨2型糖尿病(T2DM)合并脑卒中血清学指标的检测及临床意义,为防治T2DM合并脑卒中的发病提供依据。方法选取本院内科2012年11月至2014年5月收治的80例T2DM患者为研究对象,以是否合并脑卒中分为T2DM合并脑卒中组(36例)和T2DM组(44例)。分别测量两组患者FIB、DD、WBC、LDL、HDL、hs-CRP、SAA、GGT、TG和TC等血清学指标。结果 (1)T2DM合并脑卒中组中的FIB、DD、TC、TG、hs-CRP、SAA和GGT水平显著高于T2DM组,差异均有统计学意义(P<0.05)。(2)多因素非条件logistic回归分析结果显示,DD、TC、TG、hs-CRP、SAA和GGT是独立危险因素。结论 DD、TC、TG、hs-CRP、SAA和GGT可作为糖尿病合并脑卒中的有效血清学指标,对监测疾病的发生发展具有重要意义。

Objective To explore type II diabetes mellitus（ T2DM） and its clinical significance of serum markers complicated by stroke,to provide the basis for the prevention of stroke onset of T2 DM. Methods From November 2012 through May 2014,80 cases of T2 DM patients were treated for the study,based on whether the merger of T2 DM stroke into stroke group（ 36 cases） and T2 DM group（ 44 cases）. Two groups of patients were measured serum markers FIB,DD,WBC,LDL,HDL,hs-CRP,SAA,GGT,TG and TC and the like.Results（ 1） T2 DM complicated by stroke group FIB,DD,TC,TG,hs-CRP,SAA and GGT levels were significantly higher than T2 DM group,the differences were statistically significant（ P〈0. 05）.（ 2） More nonconditional logistic regression analysis showed that,DD,TC,TG,hs-CRP,SAA and GGT was an independent risk factor. Conclusions DD,TC,TG,hs-CRP,SAA and GGT as diabetes mellitus and stroke effective serological indicator for monitoring the development of the disease is important.