经治疗妊娠的不孕女性早孕期甲状腺功能检测结果分析

目的探讨排卵障碍和排卵正常的不孕女性经治疗妊娠后早孕期亚临床甲状腺功能减退发生情况，为临床提供参考。方法回顾性分析2014年5月1日至2015年3月1日治疗后妊娠的不孕女性252例，根据患者不孕原因分为排卵障碍组112例、排卵正常组140例，比较两组年龄，早孕期甲状腺功能三项、妊娠合并亚临床甲状腺功能减退症发生率、甲状腺过氧化物酶抗体（TPO-Ab）阳性率。结果排卵障碍组比排卵正常组不孕女性早孕期的血清促甲状腺激素（TSH）水平明显升高，差异有统计学意义（P〈0．05）；早孕期亚临床甲状腺功能减退症发生率高，差异有统计学意义（P〈0．05）；早孕期TPO-Ab阳性率低，差异无统计学意义（P〉0．05）。结论排卵障碍不孕女性经治疗早孕期亚临床甲状腺功能减退症发生率明显增高。

Objective To explore the occurrence of subclinical hypothyroidism in the early pregnant women with ovulation disorder and normal ovulation infertility after treatment, provide reference for clinical. Mehtods Retrospective analysis of 252 cases of pregnant women who were treated in The First Affiliated Hospital of Soochow University reproductive medicine center from May 1, 2014 to March 1, 2015, were performed, cases of pregnant women with infertility, according to the causes of infertility were divided into 112 cases of ovulation disorder group and 140 cases of normal group. The two groups were compared with early pregnancy TSH, FT4, TPOAb, the incidence of subclinical hypothyroidism, TPO-Ab positive rate. Results the serum levels of TSFI in the early pregnancy of the infertile women with ovulation disorder group, were significantly higher than those of the normal group, The difference was statistically significant （ P〈0.05 ） , The incidence of subclinical hypothyroidism was higher, the difference was statistically significant （ P〈0.05 ） , The positive rate of TPO-Ab was lower, and the difference was not statistically significant （ P〉0.05 ） ; Conclusion The incidence of subclinical hypothyroidism in early pregnant women after treatment with ovulation disorder was significantly increased.