心绞痛与急性心梗患者血清HMGB1的临床意义

目的研究高迁移率族蛋白B1（HMGB1）和冠状动脉病变程度的关系，以探讨HMGB1在冠心病诊断和治疗中的价值。方法选取健康人群220例以及冠心病患者345例，其中心绞痛（AP）189例，急性心肌梗死（AMI）156例作为观察对象。采用酶联免疫吸附法检测血清高迁移率族蛋白B1（HMGB1）、超敏C反应蛋白（Hs-CRP）、肿瘤坏死因子-α（TNF—α）与白介素-6（IL-6）水平。结果AP患者血清HMGB1、hs-CRP、TNF—α与IL-6水平显著高于对照组（P〈0．01）；AMI患者血清HMGB1、hs-CRP、TNF—α与IL-6水平显著高于AP和对照组（P〈0．01）；血清HMGBI水平与hs—CRP、TNF-α、IL-6水平呈正相关。结论血清HMGBI浓度变化对AP和AMI具有明确诊断的价值，HMGB1可作为动脉粥样硬化性心脏痛的预测因子。

Objective In order to study the relationship between HMGB1 and the severity of coronary lesions, and explore the value of HMGBI in the diagnosis and treatment of coronary heart disease. Methods 220 cases of healthy people and 345 cases of coronary heart disease were selected, including 189 angina pectoris （ AP ） patients and 156 acute myocardial infarction （ AMI ） patients. Serum concentrations of HMGB1, hs-CRP, TNF-α and IL-6 were determined by enzyme-linked immunosorbent assay. Results Serum HMGBI, hs-CRP, TNF-α and IL-6 levels were obviously elevated in the AP group as compared with controls （ P〈0.01 ） ; those serum levels were significantly elevated in the AMI group as compared with the AP group and controls （ P〈0.01 ） ; serum HMGB1 was positively correlated with hs-CRP, TNF-α and IL-6 levels. Conclusion The change in serum levels of HMGBI is of higher accuracy in the diagnosis of patients with AP and AMI, HMGB1 can be used as a predictor of atherosclerotic heart disease.