内皮素1、Toll样受体4与冠状动脉慢血流关系的研究

The relationship between Endothelin-1,Toll-like receptor-4 and coronary slow flow

目的:探讨血浆内皮素1(ET-1)、Toll样受体4(TLR-4)与冠状动脉慢血流的关系。方法:入选2014-01-2015-07于本院行冠状动脉造影的39例冠状动脉慢血流患者为试验组,同期冠状动脉造影正常的40例患者为对照组,采用酶联免疫吸附法(ELISA)测定两组患者血浆ET-1、TLR-4水平。结果:两组平均血流帧数的差异有统计学意义(P<0.001);冠状动脉慢血流患者中男性比例(79%)远大于女性;两组平均红细胞血红蛋白浓度(MCHC)、红细胞分布宽度变异系数(RDW-CV)、ET-1、TLR-4之间的差异有统计学意义(均P<0.05),其他实验室指标的差异无统计学意义。多因素logistic回归分析示ET-1、TLR-4与冠状动脉慢血流独立相关(均P<0.05);ET-1与TLR-4的Spearman相关系数为0.439(P<0.001),TLR-4与MCHC的Spearman相关系数为0.277(P=0.014),提示TLR-4与ET-1、MCHC显著相关,但相关关系并不密切(r<0.5)。结论:ET-1、TLR-4以及红细胞变形可能参与了冠状动脉慢血流的发生、发展。

Objective：To analyze the relationship between plasma ET-1,TLR-4and coronary slow flow（CSF）.Method：From January 2014 to July 2015,79 patients with angiographically proved stenosis less than 40%were divided into CSF group（n=39）and control group（n=40）.The concentrations of plasma ET-1and TLR-4were determined by using ELISA.Result：The frame counts between 2groups were significant different（P〈0.001）.In CSF group,the proportion of males（79%）was higher than females.There was significant difference in MCHC,RDW-CV,ET-1,TLR-4between two groups（P〈0.05）.Multiple logostic regression analysis showed that ET-1,TLR-4were independently associated with CSF（P〈0.05）.The plasma level of TLR-4was positively related to plasma ET-1（r=0.439,P〈0.001）and MCHC（r=0.277,P=0.014）,but the corrections were weak（r0.5）.Conclusion：ET-1,TLR-4and RBC deformability may play some pathophysiologic roles in CSF.