急性冠状动脉综合征患者血清中介素水平及其临床意义

Clinical significances of serum intermedin in patient with acute coronary syndrome

目的:探讨急性冠状动脉综合征(ACS)患者血清中介素(IMD)水平及临床意义。方法:选取ACS患者55例(ACS组),健康对照组30例,采用酶联免疫吸附试验检测血清IMD、超敏-C反应蛋白(hs-CRP)水平。依据冠脉造影结果评估冠脉狭窄程度,以Gensini积分总和表示。采用Pearson相关分析方法分析血清IMD水平与冠脉狭窄程度的相关性。结果:ACS组血清IMD、hs-CRP水平显著高于对照组(均P<0.01),血清IMD与Gensini积分正相关(r=0.872,P<0.01),ACS组血清IMD与hs-CRP呈正相关(r=0.650,P<0.01)。结论:ACS患者血清IMD水平升高,其水平与冠脉病变严重程度有关,IMD可能通过抗炎症发挥心肌保护作用,或可成为ACS诊断与危险评估有价值的生物标志物。

Objective：To examine the serum content of intermedin（IMD）and its clinical significance in patients with acute coronary syndrome（ACS）.Method：The 55 acute coronary syndrome patients（ACS group,n=55）were enrolled in this study.Healthy individuals were employed as the control group（n=30）.The serum levels of IMD and hs-CRP were determined by enzyme-linked immunosorbent assay.The severity of coronary artery stenosis in patients with ACS was measured by coronary angiography and expressed by the sum of Gensini scores.The correlation of IMD with the severity of coronary artery stenosis were analyzed with Pearson correlation analysis.Result：Serum IMD and hs-CRP levels were markedly higher in ACS patients than that in controls（both P〈0.01）.The increased serum IMD were positively correlated with Gensini scores（r=0.872,P〈0.01）.Serum IMD levels was positively correlated with hs-CRP（r=0.650,P〈0.01）.Conclusion：Plasma IMD levels are increased in patients with ACS,and associate with the severity of coronary artery stenosis.Cardio-protective effects of IMD is due to the inhibition of inflammatory,which can be a valuable biomarker in the diagnosis and assessment of ACS.