干扰素联合炎唬宁治疗对手足口病患儿血清细胞因子及免疫球蛋白水平的影响

The Effect of Interferon Combined with Andrographolide on Serum Cytokines and Immunoglobulins Levels in Treatment of Hand-foot-mouth Disease Children

目的探讨干扰素联合炎唬宁治疗对手足口病患儿血清细胞因子及免疫球蛋白水平的影响。方法选择2014年2月至2015年3月涉县医院儿科接诊的90例手足口病患儿进行研究。按照随机数字表法均分为对照组和观察组,各45例。对照组采用单纯干扰素治疗(按照8万U/kg用量选用α-2b干扰素,进行肌内注射,每日1次),观察组采用干扰素联合炎琥宁治疗(按照10 mg/kg的用量加入到浓度为5%葡萄糖液中静脉注射,每日1次)。治疗5 d后比较两组患儿血清细胞因子水平[肿瘤坏死因子(TNF)α、白细胞介素(IL)-1β、IL-6、IL-10]、免疫球蛋白水平(Ig M、Ig G、Ig A)的变化情况及其治疗效果。结果治疗后,两组患儿的血清细胞因子均有所降低,观察组TNF-α、IL-1β、IL-6、IL-10均低于对照组[(35±8)ng/L比(40±9)ng/L,(12±5)ng/L比(16±5)ng/L,(15±3)ng/L比(17±3)ng/L,(25±7)ng/L比(29±8)ng/L],差异有统计学意义(P<0.05);观察组Ig M、Ig G、Ig A均显著高于对照组[(1.4±0.3)g/L比(1.2±0.3)g/L,(9.4±0.4)g/L比(9.2±0.4)g/L,(1.4±0.3)g/L比(1.2±0.3)g/L],差异有统计学意义(P<0.05);观察组的总有效率显著高于对照组[95.6%(43/45)比73.3%(33/45)],差异有统计学意义(P<0.05)。结论干扰素联合炎唬宁治疗手足口病患儿的抗炎效果良好,可显著提高疗效,值得临床推广。

Objective To evaluate the effect of interferon combined with andrographolide on serum cytokines and immunoglobulins levels in treatment of hand-foot-mouth disease（ HFMD） children. Methods Total of 90 HFMD patients in Shexian County Hospital from Feb. 2014 to Mar. 2015 were included in the study. According to random number table method they were divided into control group and observation group,45 cases each group. The control group was treated with simple interferon therapy（ 80 000 U / kg,interferonα-2b,intramuscular injection,once per day）; the observation group was treated by interferon combined with andrographolide（ 10 mg / kg,added to 5% glucose solution,intravenous injection,once per day）. The serum levels of cytokines（ TNF-α,IL-1β,IL-6,IL-10）,the level of immunoglobulin（ Ig M,Ig G,Ig A） and the efficacy of the two groups after 5 days of treatment were compared. Results After treatment,serum cytokines of both groups were decreased,the observation group＇ s TNF-α,IL-1β,IL-6,IL-10 were significantly lower than the control group＇s[（ 35 ± 8） ng / L vs（ 40 ± 9） ng / L,（ 12 ± 5） ng / L vs（ 16 ± 5） ng / L;（ 15 ± 3） ng / L vs（ 17 ± 3） ng/L;（ 25 ± 7） ng/L vs（ 29 ± 8） ng/L]（ P 〈0. 05）; immunoglobulin levels,Ig M,Ig G,Ig A of the observation group were higher than the control group [（ 1. 4 ± 0. 3） g / L vs（ 1. 2 ± 0. 3） g / L,（ 9. 4 ±0. 4） g / L vs（ 9. 2 ± 0. 4） g / L,（ 1. 4 ± 0. 3） g / L vs（ 1. 2 ± 0. 3） g / L],the differences were statistically significant（ P 〈0. 05）; the total effective rate of the observation group was significantly higher than the control group[95. 6%（ 43 /45） vs 73. 3%（ 33 /45） ],the difference was statistically significant（ P 〈0. 05）.Conclusion The anti-inflammatory effect of interferon combined with andrographolide in treatment of HFMD children is good,which can significantly improve the efficacy,thus is worthy of promotion in clinical.