越鞠甘麦大枣汤快速治疗产后抑郁子代抑郁症的探索

Rapid Treatment of Yueju Ganmai Dazao Decoctionon Postpartum Depression-offspring Depression

目的:应用产后抑郁子代动物模型观察母代产后抑郁对于子代的影响,并研究越鞠甘麦大枣汤对于产后抑郁子代抑郁行为的改善作用。方法:成功建立产后抑郁子代动物模型后,Balb/c子代雄鼠分为正常子代组(CTL-F1,16只),产后抑郁子代组(PPD-F1,8只),产后抑郁子代给予生理盐水组(Veh,8只)及产后抑郁子代给予越鞠甘麦大枣汤组(YG,8只)。Veh按10 m L·kg-1给予生理盐水,YG按8.3 g·kg-1给予越鞠甘麦大枣汤,应用悬尾测试及新奇环境摄食测试观察子代小鼠的抑郁行为。结果:PPD-F1悬尾不动时间显著长于CTL-F1,但单位体重摄食量较后者显著降低。与Veh相比,给予越鞠甘麦大枣汤可使PPD-F1不动时间显著缩短,且摄食量显著增加。结论:产后抑郁子代更易表现出抑郁行为,而越鞠甘麦大枣汤可快速有效地改善该抑郁行为。

Objective： To observe effect of postpartum depression on offspring by taking postpartum depression offspring animal model, and to identify treatment of Yueju Ganmai Dazao decoction can improve depressive behavior of postpartum depression offspring. Method： Afetr animal model of postpartum depression was successfully established, Balb / c male offspring mice were divided as normal group（ CTL-F1, n = 16）,postpartum depression offspring group（ PPD-F1, n = 8）, postpartum depression offspring treated with saline（ Veh,n = 8） and postpartum depression offspring treated with Yueju Ganmai Dazao decoction（ YG,n = 8）.Veh treated with normal saline by 10 m L·kg- 1,YG given Yueju Ganmai Dazao decoction with 8. 3 g·kg- 1,tail suspension test and novelty suppressed-feeding test were used to observe depressive behavior of mice. Result：Immobility time of PPD-F1 was significantly longer than that of CTL-F1 in tail suspension test, food intake significantly decreased in novelty suppressed-feeding test. However,compared with Veh,immobility time of YG significantly shortened and its food intake significantly increase. Conclusion： Postpartum depression offspring more easily shows depressive behavior, Yueju Ganmai Dazao decoction can quickly and effectively improve thisdepressive behavior.