活血解毒丸对急性乳腺炎患者炎症细胞因子的影响

Effect of Huoxue Jiedu Pill on Cytokines in Patients with Acute Mastitis

目的:探讨活血解毒丸对急性乳腺炎患者炎症细胞因子的影响。方法:2012年5月1日—2015年5月1日收治的201例急性乳腺炎女性患者,随机分为治疗组和安慰剂对照组,治疗组96例,对照组105例。两组患者在抗生素治疗的基础上分别接受活血解毒丸或安慰剂治疗7 d。比较两组患者治疗前后的血常规,血清和乳汁白细胞介素-6(IL-6)和C-反应蛋白(CRP),比较两组治疗总有效率。结果:治疗组和对照组的总有效率分别为100%,85.7%。治疗组和对照组治疗后血清IL-6,CRP水平均较治疗前显著下降(P<0.05),治疗组治疗后血清IL-6,CRP水平显著低于对照组(P<0.05)。治疗组和对照组治疗后乳汁IL-6,CRP水平均较治疗前显著下降(P<0.05),治疗组治疗后乳汁IL-6和CRP水平显著低于对照组(P<0.05)。治疗组和对照组治疗后白细胞、中性粒细胞、淋巴细胞和单核细胞计数均显著降低(P<0.05),治疗组白细胞和中性粒细胞计数明显低于对照组(P<0.05)。结论:活血解毒丸结合西医治疗急性乳腺炎安全、有效,值得在临床上广泛应用。

Objective： To investigate the effect of Huoxue Jiedu pill on cytokines in patients with acute mastitis. Method： The 201 patients with acute mastitis in our hospital between May 1st2012 to May 1st2015 were randomly divided into treatment group and control group,with 96 patients in treatment group and 105 patients in control group. Patients were treated with Huoxue Jiedu pill or placebo for 7 days on basis of antibiotic therapy.Results of routine blood test,serum and milk interleukin-6（ IL-6） and C-reactive protein（ CRP） levels before and after treatment in two groups were compared. The total effective rates of two groups were compared. Result： Total effective rate was 100% in treatment group and 85. 7% in control group respectively. Serum IL-6 and CRP levels were decreased significantly after treatment in both groups（ P〈 0. 05）,and the above levels in treatment group were significantly lower than those in control group after treatment（ P〈 0. 05）. Human milk IL-6 and CRP levels were decreased significantly after treatment in both groups（ P〈 0. 05）,and the above levels in treatment group were significantly lower than those in control group（ P 〈 0. 05）. Leukocyte,neutrophil,lymphocyte and monocyte counts were decreased significantly after treatment in both groups（ P 〈 0. 05）. Leukocyte and monocyte counts in treatment group were significantly lower than those in control group（ P〈 0. 05）. Conclusion： Huoxue Jiedu pill combined with western medicine is safe and effective for acute mastitis,thus is worthy of widespread application.