沙丁胺醇联合乌司他丁对COPD患者腹腔镜手术时呼吸功能、炎症及氧化应激反应的影响

Effects of salbutamol combined with ulinastatin on respiratory function,inflammation and oxidative stress in COPD patients with laparoscopic surgery

目的:分析沙丁胺醇联合乌司他丁对慢性阻塞性肺疾病(COPD)患者腹腔镜手术时呼吸功能、炎症及氧化应激反应的影响。方法:将在本院接受腹腔镜治疗的76例COPD患者纳入研究,随机分为2组,观察组(n=38)接受沙丁胺醇联合乌司他丁治疗,对照组(n=38)接受单纯沙丁胺醇治疗,检测所有患者术中呼吸功能、炎症因子水平、氧化应激水平差异。结果:观察组接受治疗后术中血氧饱和度(SpO2)、胸肺顺应性(Compl)水平高于对照组,呼气末二氧化碳分压(PE TCO2)、气道压(Paw)、气道阻力(Raw)水平低于对照组(P<0.05);观察组α1抗胰蛋白酶(AAT)、血沉(ESR)、新蝶呤(NPT)、α1酸性糖蛋白(AAG)、淀粉样蛋白A(SAA)水平均明显低于对照组(P<0.05);观察组接受治疗后谷胱甘肽还原酶(GR)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GPX1)、硫氧还蛋白1(TXNL1)水平高于对照组,氧化型低密度脂蛋白受体1(LOX-1)水平较对照组低(P<0.05)。结论:COPD患者接受沙丁胺醇联合乌司他丁治疗,可以显著提升术中呼吸功能,降低全身炎症及氧化应激水平。

Objective：To analyze the effects salbutamol combined with ulinastatin on respiratory function,inflammation and oxidative stress in COPD patients with laparoscopic surgery.Methods：A total of 76 COPD patients were randomly divided into observation group（n=38）,who accepted salbutamol combined with ulinastatin treatment,and the control group（n=38）,who accepted with single salbutamol treatment.All patients were tested respiratory function and inflammation levels and different levels of oxidative stress.Results：After treatment,the observation group patients＇ in-surgery SpO2 and Compl levels were higher than those in the control group,while PE TCO2,Paw and Raw levels were lower than the control group（P〈0.05）.The in-surgery AAT,ESR,NPT,AAG and SAA levels of the observation group patients were significantly lower than those in the control group（P〈0.05）.After the treatment,the observation group patients＇ in-surgery GR,CAT,GPX1 and TXNL1levels were higher than the control group,while LOX-1level was lower than that of the control group（P〈0.05）.Conclusions：COPD patients receiving salbutamol combined with ulinastatin treatment can significantly improve the respiratory function in surgery,and reduce systemic inflammation and oxidative stress.