舌下特异性免疫治疗联合氯雷他定对过敏性鼻炎患儿血液和诱导痰指标的影响

Effect of sublingual immunotherapy combined with Loratadine on blood parameters and induced sputum indicators in children with allergic rhinitis

目的:分析舌下特异性免疫治疗联合氯雷他定对过敏性鼻炎患儿血液指标和诱导痰指标的影响。方法:选取2012年8月~2014年11月我院收治的过敏性鼻炎患儿172例作为研究对象,随机分为观察组及对照组,各86例。对照组接受单纯氯雷他定治疗,观察组接受舌下特异性免疫治疗联合氯雷他定疗法,对比两组外周血嗜酸性粒细胞(EOS)计数、淋巴细胞亚群水平、血清炎症相关因子水平、诱导痰中生长因子水平等差异。结果:观察组治疗后各个时期血EOS计数值均低于对照组(P<0.05);观察组治疗后CD3^-CD19^+、CD8^+、CD8^+CD28^-水平低于对照组,CD8^+CD28^+、CD28^+水平高于对照组(P<0.05);观察组治疗后白介素-4(IL-4)、白介素-17(IL-17)水平低于对照组,白介素-10(IL-10)、白介素-35(IL-35)、干扰素-γ(IFN-γ)水平高于对照组(P<0.05);观察组治疗后表皮生长因子(EGF)、血小板衍生生长因子(PDGF)-BB、转化生长因子β1(TGF-β1)水平高于对照组,PDGF-AA、碱性成纤维细胞生长因子(bFGF)、血管内皮生长因子(VEGF)水平低于对照组(P<0.05)。结论:过敏性鼻炎患儿接受舌下特异性免疫治疗联合氯雷他定疗法,可以有效优化机体免疫状态、恢复微环境稳态,具有积极的临床意义。

Objective：To analyze the effect of sublingual immunotherapy combined with Loratadine on blood parameters and induced sputum indicators in children with allergic rhinitis.Methods：A total of 172 cases of children with allergic rhinitis treated in our hospital from August 2012 to November 2014 were selected as research subjects and randomly divided into observation group 86 cases and control group 86 cases according to different treatment methods.Control group received Loratadine therapy alone,observation group received sublingual immunotherapy combined with Loratadine,and then differences in EOS count,lymphocyte subset levels,serum inflammation-related factor levels and growth factor levels in induced sputum between two groups were compared.Results：EOS count values of observation group at all times after treatment were lower than those of control group（P〈0.05）;CD3-CD19＋,CD8＋and CD8＋CD28-levels of observation group after treatment were lower than those of control group,and CD8＋CD28＋and CD28＋levels were higher than those of control group（P〈0.05）;IL-4and IL-17 levels of observation group after treatment were lower than those of control group,and IL-10,IL-35 and IFN-γlevels were higher than those of control group（P〈0.05）;EGF,PDGF-BB and TGF-β1levels of observation group after treatment were higher than those of control group,and PDGF-AA,bFGF and VEGF levels were lower than those of control group（P〈0.05）.Conclusions：Sublingual immunotherapy combined with Loratadine therapy for children with allergic rhinitis can effectively optimize body＇s immune status and restore microenvironment homeostasis,and it has active clinical significance.